Cefixime Trihydrate + Ofloxacin Tablets Indication Typhoid Fever ,Respiratory Tract infections, Urinary Tract infections, Surgical Prophylaxis, Soft Tissue infections. It is a third generation cephalosporin. combination of cefixime (cephalosporin) and ofloxacin (fluoroquinolone) and has unique dual mode of action i.e in this combination ofloxacin prevents nucleic acid synthesis of bacteria and cefixime inhibits bacterial cell wall synthesis.Uncomplicated urinary tract infections, otitis media, pharyngitis and tonsillitis, acute exacerbations of chronic bronchitis, uncomplicated gonorrhea (cervical/urethral).